Purkinje Nerve cell, TEM (SciPhotoLib) Purkinje Nerve cell, TEM (SciPhotoLib)

Publications

All the publications can be found on Google Scholar

Recent Structural Insights into the Molecular Architecture of Synapses
Axel T. Brunger, Richard G. Held, Yousuf A. Khan, Jeremy Leitz, Jiahao Liang, Chuchu WANG, K. Ian White
Nano-organization of the Synapse 2026
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N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
Chuchu WANG, Chunyu Zhao, Hu Xiao, Jiali Qiang, Zhenying Liu, Jinge Gu, Shengnan Zhang, Dan Li, Yaoyang Zhang, Jacqueline Burré, Jiajie Diao, Cong Liu
eLife 2024
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In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET
Richard G. Held, Jiahao Liang, Luis Esquivies, Yousuf A. Khan, Chuchu WANG, Maia Azubel, Axel T. Brunger
bioRxiv 2024
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Nonlinear dynamics of multi-omics profiles during human aging
Xiaotao Shen, Chuchu WANG, Xin Zhou, Wenyu Zhou, Daniel Hornburg, Si Wu, Michael Snyder
Nature Aging 2024
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Observing isolated synaptic vesicle association and fusion ex vivo
Jeremy Leitz, Chuchu WANG, Luis Esquivies, John J. Peters, Nisha Gopal, Richard A. Pfuetzner, Austin L. Wang, Axel T. Brunger
Nature Protocols 2024
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VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates
Chuchu WANG, Kai Zhang, Bin Cai, Jillian E. Haller, Kathryn E. Carnazza, Jiaojiao Hu, Chunyu Zhao, Zhiqi Tian, Xiao Hu, Daniel Hall, Jiali Qiang, Shouqiao Hou, Zhenying Liu, Jinge Gu, Yaoyang Zhang, Kim B. Seroogy, Jacqueline Burré, Yanshan Fang, Cong Liu, Axel T. Brunger, Dan Li, Jiajie Diao
Nature Cell Biology 2024
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Structure and topography of the synaptic V-ATPase–synaptophysin complex
Chuchu WANG, Wenhong Jiang, Jeremy Leitz, Kailu Yang, Luis Esquivies, Xing Wang, Xiaotao Shen, Richard Held, Daniel J. Adams, Tamara Basta, Lucas Hampton, Ruiqi Jian, Lihua Jiang, Michael H. B. Stowell, Wolfgang Baumeister, Qiang Guo, Axel T. Brunger
Nature 2024
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Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation
Chunyu Zhao, Jia Tu, Chuchu WANG, Wenbin Liu, Jinge Gu, Yandong Yin, Shengnan Zhang, Dan Li, Jiajie Diao, Zheng-Jiang Zhu, Cong Liu
National Science Review 2024
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Beyond the MUN domain Munc13 controls priming and depriming of synaptic vesicles
Jeremy Leitz, Chuchu WANG, Luis Esquivies, Richard A. Pfuetzner, John Jacob Peters, Sergio Couoh-Cardel, Austin L. Wang, Axel T. Brunger
Cell Reports 2024
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A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles
Nisha Gopal, Jeremy Leitz, Chuchu WANG, Luis Esquivies, Richard A. Pfuetzner, Axel T. Brunger
Current Research in Physiology 2024
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Multi-omics microsampling for the profiling of lifestyle-associated changes in health
Xiaotao Shen, Ryan Kellogg, Daniel J Panyard, Nasim Bararpour, Kevin Erazo Castillo, Brittany Lee-McMullen, Alireza Delfarah, Jessalyn Ubellacker, Sara Ahadi, Yael Rosenberg-Hasson, Ariel Ganz, Kévin Contrepois, Basil Michael, Ian Simms, Chuchu WANG, Daniel Hornburg, Michael Snyder
Nature Biomedical Engineering 2024
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Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering
Ying Lai, Chunyu Zhao, Zhiqi Tian, Chuchu WANG, Jiaqi Fan, Xiao Hu, Jia Tu, Tihui Li, Jeremy Leitz, Richard A. Pfuetzner, Zhengtao Liu, Shengnan Zhang, Zhaoming Su, Jacqueline Burré, Dan Li, Thomas C. Südhof, Zheng-Jiang Zhu, Cong Liu, Axel T. Brunger, Jiajie Diao
PNAS 2023
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Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor
Kailu Yang, Chuchu WANG, Alex J. B. Kreutzberger, K. Ian White, Richard A. Pfuetzner, Luis Esquivies, Tomas Kirchhausen, Axel T. Brunger
PNAS 2023
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massDatabase utilities for the operation of the public compound and pathway database
Xiaotao Shen, Chuchu WANG, Michael Snyder
Bioinformatics 2022
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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
Kailu Yang, Chuchu WANG, Alex J. B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard G. Held, Subu Subramanian, Kendra Marcus, Richard A. Pfuetzner, Luis Esquivies, Catherine A. Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T. Brunger
PNAS 2022
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Deep learning-based pseudo-mass spectrometry imaging analysis for precision medicine
Xiaotao Shen, Wei Shao, Chuchu WANG, Liang Liang, Songjie Chen, Sai Zhang, Mirabela Rusu, Michael Snyder
Briefings in Bioinformatics 2022
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TidyMass an object-oriented reproducible analysis framework for LC–MS data
Xiaotao Shen, Hong Yan, Chuchu WANG, Peng Gao, Caroline Johnson, Michael Snyder
Nature Communications 2022
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Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle
Kailu Yang, Chuchu WANG, K. Ian White, Richard A. Pfuetzner, Luis Esquivies, Axel T. Brunger
PNAS 2022
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Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease
Shengnan Zhang, Yu-Qing Liu, Chunyu Jia, Yeh-Jun Lim, Guoqin Feng, Enquan Xu, Houfang Long, Yasuyoshi Kimura, Youqi Tao, Chunyu Zhao, Chuchu WANG, Zhenying Liu, Jin-Jian Hu, Meng-Rong Ma, Zhijun Liu, Lin Jiang, Dan Li, Renxiao Wang, Valina L. Dawson, Ted M. Dawson, Yan-Mei Li, Xiaobo Mao, Cong Liu
PNAS 2021
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Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau
Xiaojuan Ma, Yi Zhu, Jinxia Lu, Jingfei Xie, Chong Li, Woo Shik Shin, Jiali Qiang, Jiaqi Liu, Shuai Dou, Yi Xiao, Chuchu WANG, Chunyu Jia, Houfang Long, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Rong Grace Zhai, Cong Liu, Dan Li
eLife 2020
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Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Chuchu WANG, Jia Tu, Shengnan Zhang, Bin Cai, Zhenying Liu, Shouqiao Hou, Zhijun Liu, Jiajie Diao, Zheng-Jiang Zhu, Cong Liu, Dan Li
Nature Communications 2020
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Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation
Zhenying Liu, Shengnan Zhang, Jinge Gu, Yichen Li, Xinyi Gui, Houfang Long, Chuchu WANG, Chunyu Zhao, Jinxia Lu, Zhijun Liu, Cong Liu, Dan Li
Nature Structural & Molecular Biology 2020
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Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation
Jinxia Lu, Qin Cao, Chuchu WANG, Jing Zheng, Feng Luo, Jingfei Xie, Yichen Li, Xiaojuan Ma, Lin He, David Eisenberg, James Nowick, Lin Jiang, Dan Li
Frontiers in Molecular Neuroscience 2019
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In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau
Shengnan Zhang, Chuchu WANG, Jinxia Lu, Xiaojuan Ma, Zhenying Liu, Dan Li, Zhijun Liu, Cong Liu
Int. J. Mol. Sci. 2019
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Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization
Zhenying Liu, Chuchu WANG, Yichen Li, Chunyu Zhao, Tongzhou Li, Dan Li, Shengnan Zhang, Cong Liu
Journal of Biological Chemistry 2018
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Versatile Structures of α-Synuclein
Chuchu WANG, Chunyu Zhao, Dan Li, Zhiqi Tian, Ying Lai, Jiajie Diao, Cong Liu
Frontiers in Molecular Neuroscience 2016
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Photoluminescence Properties of La1/3NbO3: Sm3+ Coupled with Sr2+, Ba2+ and Bi3+ Under Near-UV Excitation
Yu Du, Kai Huang, Jian Zhang, Chuchu WANG, Xin Chu, Chao Hou, Shuang Feng
Chemical Journal of Chinese Universities 2013